Publications

Context dependence

59. Context-dependent significance of London dispersion
L. A. Gravillier, S. L. Cockroft*. Acc. Chem. Res., DOI: 10.1021/acs.accounts.3c00625 (2023) Citations

-Featured in Acc. Chem. Res. 'Special Issue - Dispersion Interactions in Chemistry'

Experimental quantification of halogen∙∙∙arene van der Waals contacts

58. Experimental quantification of halogen∙∙∙arene van der Waals contacts
A. M. L. West, N. Dominelli-Whiteley, I. V. Smolyar, G. S. Nichol, S. L. Cockroft*. Angew. Chem. Int. Ed., 63, e202309682 (2023) Citations

-Featured in Chemistry Views, 'Molecular balances used to measure halogen∙∙∙arene interactions'

Image showing energetic dissection of H-bonds

57. Dissecting solvent effects on hydrogen bonding
N. Y. Meredith, S. Borsley, I. V. Smolyar, G. S. Nichol, C. M. Baker, K. B. Ling, S. L. Cockroft*. Angew. Chem. Int. Ed., 61, e202206604 (2022) Citations

-Featured in Nature Reviews Chemistry, 'Weighing up solvent effects', and as a Hot Paper in Angew. Chem.

Chemical and biological modifications diagram

56. Functionalised nanopores: Chemical and biological modifications
D. F. Cairns-Gibson, S. L. Cockroft*. Chem. Sci., 13, 1369-1882 (2022). Citations

Reversible elimination process

54. Reversible reductive elimination in Al(II) dihydrides
R. L. Falconer, G. S. Nichol, I. V. Smolyar, S. L. Cockroft, M. J. Cowley*. Angew. Chem. Int. Ed., 60, 2047-2052 (2021). Citations

DNA strands

53. Strand displacement in DNA-based nanodevices and logic
A. Bader, S. L. Cockroft*. Book chapter in 'DNA- and RNA-Based Computing Systems' (E. Katz, Ed.), Wiley-VCH (2021). Citations

Platinum complex

52. Reversible stimuli-responsive chromism of a cyclometallated platinum(II) complex
Q. Zheng, S. Borsley, T. Tu, S. L. Cockroft*. Chem. Commun., 56, 14705-14708 (2020). Citations

Molecular knot

51. Transmembrane ion channels formed by a star of David [2]catenane and a molecular pentafoil knot
D. P. August, S. Borsley, S. L. Cockroft, F. della Sala, D. A. Leigh,* S. J. Webb. J. Am. Chem. Soc., 142, 18859-18865 (2020). Citations

Daigram of molecular effects

50. Quantifying through-space substituent effects
R. J. Burns, I. K. Mati, K. B. Muchowska, C. Adam, S. L. Cockroft*. Angew. Chem. Int. Ed., 59, 16717-16724 (2020). Citations

-Featured in: Nature Reviews Chemistry and as a Hot Paper in Angew. Chem. -Also see commentary in Chemistry World

Ion channels

49. Switchable foldamer ion channels with antibacterial activity
A. D. Peters, S. Borsley, F. della Sala, D. F. Cairns-Gibson, M. Leonidou, J. Clayden, George F. S. Whitehead, I. Vitorica-Yrzebal, E. Takano, J. Burthem, S. L. Cockroft, S. Webb*. Chem. Sci., 11, 7023-7030 (2020). Citations

CArbonyl interactions

48. Reconciling electrostatic and n→π* orbital contributions in carbonyl interactions
K. B. Muchowska, D. J. Pascoe, S. Borsley, I. V. Smolyar, I. K. Mati, C. Adam, G. S. Nichol, K. B. Ling, S. L. Cockroft*. Angew. Chem. Int. Ed., 59, 14602-14608 (2020). Citations
- Featured as a Hot Paper in Angew. Chem.

Toehold sequenced DNS

47. Conformational enhancement of fidelity in toehold-sequestered DNA nanodevices
A. Bader, S. L. Cockroft*. Chem. Commun., 56, 5135-5138 (2020). Citations

Chalcogen interactions

46. The importance of 1,5-oxygen-chalcogen interactions in enantioselective isochalcogenourea catalysis
C. M. Young, A. Elmi, D. J. Pascoe, R. K. Morris, C. McLaughlin, A. M. Woods, A. B. Frost, A. de la Houpliere, K. B. Ling, T. K. Smith, A. M. Z. Slawin, P. H. Willoughby*, S. L. Cockroft*, A. D. Smith*. Angew. Chem. Int. Ed., 59, 3705-3710 (2020). Citations

MEtallophilic interactions

45. The energetic significance of metallophilic interactions
Q. Zheng, S. Borsley, G. S. Nichol, F. Duarte, S. L. Cockroft*. Angew. Chem. Int. Ed., 58, 12617-12623 (2019). Citations

- Featured as a Hot Paper in Angew. Chem.

Lcick reaction mechanism

44. Synthetically diversified protein nanopores: Resolving click reaction mechanisms
M. M. Haugland, S. Borsley, D. F. Cairns-Gibson, A. Elmi, S. L. Cockroft*. ACS Nano, 13, 4101–4110 (2019). Citations

Cage complex

43. Electrostatic forces in field-perturbed equilibria: nanopore analysis of cage complexes
S. Borsley, M. M. Haugland, S. Oldknow, J. A. Cooper, M. J. Burke, A. Scott, W. Grantham, J. Vallejo, E. K. Brechin, P. J. Lusby,* S. L. Cockroft*. Chem (Cell Press), 5, 1275-1292 (2019). Citations

- Featured as a Preview in Chem

DNA logic gate

42. Simultaneous G-quadruplex DNA logic
A. Bader, S. L. Cockroft*. Chem. Eur. J., 24, 4820-4824 (2018). Citations

Supramolecular cage

41. Nanopore detection of single-molecule binding within a metallosupramolecular cage
S. Borsley, J. A. Cooper, P. J. Lusby, S. L. Cockroft*. Chem. Eur. J., 24, 4542-4546 (2018). Citations

RNA mechanism

40. An RNA-dependent mechanism for transient expression of bacterial translocation filaments
D. Wang, S. P. McAteer, A. B. Wawszczyk, C. D. Russell, A. Tahoun, A. Elmi, S. L. Cockroft, D. Tollervey, S. Granneman, J. J. Tree*, D. L. Gally*. Nucleic Acids Res., 46, 3366-3381 (2018). Citations

Insitu functionalisation

39. In situ synthetic functionalization of a transmembrane protein nanopore
S. Borsley, S. L. Cockroft*. ACS Nano, 12, 786-794 (2018). Citations

Peptaibol-mimetic Aib foldamers

38. The role of terminal functionality in the membrane and antibacterial activity of peptaibol-mimetic Aib foldamers
C. Adam, A. D. Peters, M. G. Lizio, G. F. S. Whitehead, J. A. Cooper, S. L. Cockroft, J. Clayden*, S. J. Webb*. Chem. Eur. J., 24, 2249-2256 (2018). Citations

-Featured as a Hot Paper in Chem. Eur. J.

Chalcogen bonding interactions

37. The origin of chalcogen-bonding interactions
D. J. Pascoe, K. B. Ling, S. L. Cockroft*. J. Am. Chem. Soc., 139, 15160-15167 (2017). Citations

Anion screening

36. Screening solvent effects in anion recognition
S. L. Cockroft*. Chem (Cell Press), 3, 383-384 (2017). Citations

RNA sequences

35. High-throughput RNA structure probing reveals critical folding events during early 60S ribosome assembly in yeast
E. Burlacu, F. Lackmann, L.-C. Aguilar, S. Belikov, R. van Nues, C. Trahan, R. D. Hector, N. Dominelli-Whiteley, S. L. Cockroft, L. Wieslander, M, Oeffinger, S. Granneman*. Nature Commun., 8, Article Number 714 (2017). Citations

Molecules interacting

34. Structural evidence for the covalent modification of FabH by 4,5-dichloro-1,2-dithiol-3-one (HR45)
A. G. Ekström, V. Kelly, J. Marles-Wright, S. L. Cockroft, D. J. Campopiano*. Org. Biomol. Chem. 15, 6310–6313 (2017). Citations

Molecular motor

33. Defocused imaging of UV-driven surface-bound molecular motors
B. Krajnik, J. Chen, M. A. Watson, S. L. Cockroft, B. L. Feringa*, J. C. Hofkens*. J. Am. Chem. Soc., 139 (21), 7156–7159 (2017). Citations

Dagram showing cooperativity of H-bonding

32. Strong short-range cooperativity in H-bond chains
N. Dominelli-Whiteley, J. J. Brown, K. B. Muchowska, I. K. Mati, C. Adam, T. A. Hubbard, A. Elmi, A. J. Brown, I. A. W. Bell, S. L. Cockroft*. Angew. Chem. Int. Ed., 56 (26), 7658–7662 (2017). Citations

Chiral molecules

31. Discrimination of supramolecular chirality using a protein nanopore
J. A. Cooper, S. Borsley, P. J. Lusby, S. L. Cockroft*. Chem. Sci. 8, 5005–5009 (2017). Citations

-Featured in the themed collection International Symposium on Macrocyclic & Supramolecular Chemistry (ISMSC) in conjunction with ISACS

Membrane messaging

30. Transmembrane signalling: Membrane messengers
S. L. Cockroft*. Nature Chem., 9 (5), 406–407 (2017). Citations

Intramolecular interactions

29. The limit of intramolecular H-bonding
T. A. Hubbard, A. J. Brown, I. A. W. Bell, S. L. Cockroft*. J. Am. Chem. Soc., 138 (46), 15114–15117 (2016). Citations

-Featured in top ten "most read" articles in J. Am. Chem. Soc. Nov '16 to Jan '17

A molecular machine

28. Man-made molecular machines: membrane bound
M. A. Watson, S. L. Cockroft*. Chem. Soc. Rev., 45, 6118–6129 (2016). Citations

-Featured as a Hot Article in ChemSocRev
-Featured in: ChemSocRev Emerging Investigators 2016 themed collection

Transmembrane pore

27. Length-dependent formation of transmembrane pores by 310 helical aminoisobutyric acid foldamers
J. E. Jones, V. Diemer, C. Adam, J. Raftery, R. E. Ruscoe, J. Sengel, M. I. Wallace, A. Bader, S. L. Cockroft, J. Clayden*, S. J. Webb*. J. Am. Chem. Soc., 138 (2), 688–695 (2016). Citations

Nanoactuator

26. An autonomously reciprocating transmembrane nanoactuator
M. A. Watson, S. L. Cockroft*. Angew. Chem. Int. Ed., 55 (4), 1345–1349 (2016). Citations

-Featured as a Hot Paper in Angew. Chem. Int. Ed.

Dispersion forces

25. Can dispersion forces govern aromatic stacking in an organic solvent?
L. Yang, J. B. Brazier, T. A. Hubbard, D. M. Rogers, S. L. Cockroft*. Angew. Chem. Int. Ed., 55 (3), 912–916 (2016). Citations

-Highlighted in Chemistry Views

Solvophobic effects

24. Quantifying solvophobic effects in non-polar cohesive interactions
L. Yang, C. Adam, S. L. Cockroft*. J. Am. Chem. Soc., 137 (32), 10084–7 (2015). Citations

Nanopore diagram

23. DNA modulates solvent isotope effects in a nanopore
M. A. Watson, S. L. Cockroft*. Chem. Commun., 51, 12243–6 (2015). Citations

Gecko on a molecule

22. Partitioning solvophobic and dispersion forces in alkyl and perfluoroalkyl cohesion
C. Adam, L. Yang, S. L. Cockroft*. Angew. Chem. Int. Ed., 54 (4), 1164–7 (2015). Citations

Molecules as paintings in an art gallery

21. Can non-polar hydrogen atoms accept hydrogen bonds?
L. Yang, T. A. Hubbard,S. L. Cockroft*. Chem. Commun., 50 (40), 5212–5214 (2014). Citations

-Featured in: ChemComm Emerging Investigators 2014 themed collection

Molecules on different sides of a membrane

18. Seeing through solvent effects using molecular balances
I. K. Mati, C. Adam, S. L. Cockroft*. Chem. Sci., 4, 3965-72 (2013). Citations

Electrostatic forces

17. Electrostatic modulation of aromatic rings via explicit solvation of substituents
K. B. Muchowska, C. Adam, I. K. Mati, S. L. Cockroft*. J. Am. Chem. Soc., 135, 9976-79 (2013). Citations

Four ring molecules

15. Transcription forms and remodels supercoiling domains unfolding large-scale chromatin structures
C. Naughton, N. Avlonitis, S. Corless, J. G. Prendergast, I. K. Mati, P. P. Eijk, S. L. Cockroft, M. Bradley, B. Ylstra, N. Gilbert*. Nature Struct. Mol. Biol., 20, 387-95 (2013). Citations

-Featured in: Nature Struct. Mol. Biol. News & Views

Biotinylated channels

14. Palladium(II)-mediated assembly of biotinylated ion channels
C. P. Wilson, C. Boglio, L. Ma, S. L. Cockroft, S. J. Webb*. Chem. Eur. J., 17, 3465-73 (2011). Citations

DNA polymerase function

13. Real-time monitoring of DNA polymerase function and stepwise single-nucleotide DNA strand translocation through a protein nanopore
J. Chu, M González-López, S. L. Cockroft, M. Amorin, M. R. Ghadiri*. Angew. Chem. Int. Ed., 49, 10106-9 (2010). Citations

-Featured in: Chemistry World | Nano Today

Molecular balance

12. Molecular balances for quantifying non-covalent interactions
I. K. Mati, S. L. Cockroft*. Chem. Soc. Rev., 39, 4195-205 (2010). Citations

Eyes with a molecule for an iris

11. Biological nanopores for single-molecule biophysics
L. Ma, S. L. Cockroft*. ChemBioChem, 11, 25-34 (2010). Citations

Edge-to-face aromatic structures

10. Desolvation and substituent effects in edge-to-face aromatic interactions
S. L. Cockroft*, C. A. Hunter*. Chem. Commun., 3961-3 (2009). Citations

DNA polymerase activity

9. A single-molecule nanopore device detects DNA polymerase activity with single-nucleotide resolution
S. L. Cockroft, J. Chu, M. Amorin, M. R. Ghadiri*. J. Am. Chem. Soc., 130, 818-20 (2008). Citations

-Featured in: Nature | Nature Nanotechnology | ACS Chemical Biology

Molecular circuit

8. Modular multi-level circuits from immobilized DNA-based logic gates
B. M. Frezza, S. L. Cockroft, M. R. Ghadiri*. J. Am. Chem. Soc., 129, 14875-9 (2007). Citations

-Featured in: Nature

Aromatic stacking

7. Substituent effects on aromatic stacking interactions
S. L. Cockroft, J. Perkins, C. Zonta, H. Adams, S. E. Spey, C. M. R. Low, J. G. Vinter, K. R. Lawson, C. J. Urch, C. A. Hunter*. Org. Biomol. Chem., 5, 1062-80 (2007). Citations

Double-mutant cycle

6. Chemical double-mutant cycles: Dissecting non-covalent interactions
S. L. Cockroft, C. A. Hunter*. Chem. Soc. Rev., 36, 172-88 (2007). Citations

-Featured in: Supramolecular Chemistry Collection

Chemical communications cover

5. Desolvation tips the balance: Solvent effects on aromatic interactions
S. L. Cockroft, C. A. Hunter*. Chem. Commun., 36, 3806-8 (2006). Citations

False-colour molecular image

4. Electrostatic control of aromatic stacking interactions
S. L. Cockroft, C. A. Hunter*, K. R. Lawson, J. Perkins, C. J. Urch. J. Am. Chem. Soc., 127, 8594-5 (2005). Citations

Three molecules side-by-side

3. Experimental measurement of noncovalent interactions between halogens and aromatic rings
H. Adams, S. L. Cockroft, C. Guardigli, C. A. Hunter*, K. R. Lawson, J. Perkins, S. E. Spey, C. J. Urch, R. Ford. ChemBioChem, 5, 657-65 (2004). Citations

Crystal nucleation

2. A 1H NMR study of crystal nucleation in solution
A. Spitaleri, C. A. Hunter*, J. F. McCabe, M. J. Packer, S. L. Cockroft. CrystEngComm, 6, 489-493 (2004). Citations

Other Published Contributions

Diagram of molecular effects

9. Commentary: Feeling the effects
S. G. Davey*, Nature Reviews Chemistry, (2020).

Nanomachine
Book cover

5. Book review: Non-Covalent Interactions in the Synthesis and Design of New Compounds
S. L. Cockroft*, Appl. Organometal. Chem., DOI: 10.1002/aoc.3872 (2017).

Hydrogen bonding example

4. Commentary: New type of hydrogen bond discovered
D. Bradley*, Chemistry World, (2016).

A ring of aromatic molecules

3. Commentary: The silvery life of pi
D. Bradley*, Chemistry Views, DOI: 10.1002/chemv.201500052 (2015).

Palladium surface

2. Commentary: An open and shut case for palladium
L. Howes*, Chem. Biol. (RSC) 3(9) B66 (2008).